Publication研究成果
| 2020年 | 2019年 | 2018年 |
| 2017年 | 2016年 | 2015年 |
| 2014年 |
| 2020年 | 2019年 | 特許 |
論文（Paper）
| Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture | Abugomaa A, Elbadawy M, Yamanaka M, Goto Y, Hayashi K, Mori T, Uchide T, Azakami D, Fukushima R, Yoshida T, Shibutani M, Yamashita R, Kobayashi M, Yamawaki H, Shinohara Y, Kaneda M, Usui T, Sasaki K. Scientific Reports volume 10, Article number: 9393 (2020) |
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| Development of Prostate Cancer Organoid Culture Models in Basic Medicine and Translational Research | Elbadawy M, Abugomaa A, Yamawaki H, Usui T, Sasaki K. Cancers (Basel). 2020 Mar 25;12(4) |
| Effects of several organophosphates on hepatic cytochrome P450 activities in rats | Abdou RH, Elbadawy M, Khalil WF, Usui T, Sasaki K, Shimoda M. J Vet Med Sci. 2020 Mar 25. doi: 10.1292/jvms.19-0452 |
| Effect of dapagliflozin alone and in combination with insulin in a rat model of type 1 diabetes | Sayed N, Abdalla O, Kilany O, Dessouki A, Yoshida T, Sasaki K, Shimoda M. J Vet Med Sci. 2020 Mar 11. doi: 10.1292/jvms.19-0450 |
| Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model | Elbadawy M, Yamanaka M, Goto Y, Hayashi K, Tsunedomi R, Hazama S, Nagano H, Yoshida T, Shibutani M, Yoshida T, Shibutani M, Ichikawa R, Nakahara J, Omatsu T, Mizutani T, Katayama Y, Shinohara Y, Abugomaa A, Kaneda M, Yamawaki H, Sasaki K. Biomaterials, 2020, Volume 237, April 2020, 119823 |
| Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer | Amira A, Elbadawy M, Usui T, Yamawaki H, Sasaki K. Cells. 2020, 9(1), 235 |
| Passive immunization against inhibin increases testicular blood flow in male goats. | Samir H, El Sayed MAI, Nagaoka K, Sasaki K, Abo El-Maaty AM, Karen A, Abou-Ahmed MM, Watanabe G. Theriogenology. 2020 Feb 17;147:85-91 |
| Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats | Samir H, Nyametease P, Elbadawy M, Nagaoka K, Sasaki K, Watanabe G. Theriogenology. 2020 Apr 1;146:111-119 |
| Efficacy of Juzen-taiho-to against vincristine-induced toxicity in dogs | Shinohara Y, Nishino Y, Yamanaka M, Ohmori K, Elbadawy M, Usui T, Sasaki K. J Vet Med Sci. 2019 Dec 26;81(12):1810-1816. doi: 10.1292/jvms.19-0401. |
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| Possible anti-oxidative effects of long-term administration of Juzen-taiho-to in dogs | Shinohara Y, Oyama A, Usui T, Sasaki K. J Vet Med Sci. 2019 Oct 4. doi: 10.1292/jvms.19-0380. |
| Study on colorectal cancer using air-liquid interface organoid culture method | Usui T, Sasaki K. Nihon Yakurigaku Zasshi. 2019;154(2):50-55. doi: 10.1254/fpj.154.50. |
| Establishment of a novel experimental model for muscle-invasive bladder cancer by using dog bladder cancer organoid culture | Elbadawy M, Usui T, Mori T, Tsunedomi R, Hazama S, Nabeta R, Uchide T, Fukushima R, Yoshida T, Shibutani M, Tanaka T, Masuda S, Okada R, Ichikawa R, Omatsu T, Mizutani T, Katayama Y, Noguchi S, Iwai S, Nakagawa T, Shinohara Y, Kaneda M, Yamawaki H, Sasaki K. Cancer Sci. 2019 Sep;110(9):2806-2821. doi: 10.1111/cas.14118. |
| Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression | Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Front Vet Sci. 2019 Apr 18; 6:121 |
| Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer | Elbadawy M, Usui T, Yamawaki H, Sasaki K. Int J Mol Sci. 2019, 20, 2340 |
| Effects of a selective casein kinase 1δ and ε inhibitor on FcεRI expression and IgE-mediated immediate-type cutaneous reactions in dogs | Ohno H, Takahashi K, Yanuma N, Ogawa M, Hasegawa A, Sugita K, Kawano K, Sasaki K, Shirai J, Nagaoka K, Ohmori K. J Vet Med Sci. 2019 Dec 5;81(11):1680-1684 |
| Ovarian follicular changes and hemodynamics in Egyptian buffaloes under CIDR-PGF2α and Ovsynch-CIDR estrus synchronization treatments | Samir H, Kandiel MMM, El-Maaty AMA, Sediqyar M, Sasaki K, Watanabe G. J Reprod Dev. 2019 Oct 23;65(5):451-457 |
| Effect of interleukin-1β on occludin mRNA expression in the duodenal and colonic mucosa of dogs with inflammatory bowel disease | Ogawa M, Osada H, Hasegawa A, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Kondo H, Ohmori K. J Vet Intern Med. 2018 May;32(3):1019-1025 |
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| 肺がんオルガノイド・血管内皮細胞共培養システムを用いた細胞間相互作用メカニズムの解明 | 臼井達哉, 佐々木一昭. BIO Clinica. 2018, 34:45-49 |
| Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals | Elbadawy M, Usui T, Yamawaki H, Sasaki K. Int J Mol Sci. 2018 Oct 4;19(10). pii: E3031 |
| A stable association with PME-1 may be dispensable for PP2A demethylation - implications for the detection of PP2A methylation and immunoprecipitation | Yabe R, Tsuji S, Mochida S, Ikehara T, Usui T, Ohama T, Sato K. FEBS Open Bio. 2018 Aug 1;8(9):1486-1496 |
| Effects of leucovorin (folinic acid) in the methotrexate-treated rat brain | Ogushi N, Sasaki K, Shimoda M. J Vet Med Sci. 2018 May 18;80(5):760-765 |
| Development of an Experimental Model for Analyzing Drug Resistance in Colorectal Cancer | Elbadawy M, Usui T, Yamawaki H, Sasaki K. Cancers (Basel). 2018 May 28;10(6). pii: E164 |
| Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture | Usui T, Sakurai M, Umata K, Elbadawy M, Ohama T, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K, Kaneda M, Sasaki K. Int J Mol Sci. 2018 Apr 6;19(4). pii: E1098 |
| 三次元マウス肺がんモデルの確立とがん・血管内皮連関機構の解明 | 臼井達哉, 佐々木一昭. メディカル・サイエンス・ダイジェスト 2018, 44:189-192 |
| Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis | Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K. Mol Cancer Res. 2018 Mar;16(3):554-563 |
| Preparation of human primary colon tissue-derived organoid using air liquid interface culture | Usui T, Sakurai M, Umata K, Yamawaki H, Ohama T, Sato K. Curr Protoc Toxicol. 2018 Feb 21;75:22.6.1-22.6.7 |
| Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains | Hasegawa A, Watanabe M, Osada H, Ogawa M, Ohno H, Yanuma N, Sasaki K, Shimoda M, Shirai J, Ohmori K. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2184-2188 |
| Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells | Usui T, Sakurai M, Nishikawa S, Umata K, Nemoto Y, Haraguchi T, Itamoto K, Mizuno T, Noguchi S, Mori T, Iwai S, Nakagawa T, Yamawaki H, Ohama T, Sato K. Cancer Sci. 2017 Dec;108(12):2383-2392 |
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| The role of SET/I2PP2A in canine mammary tumors | Kake S, Tsuji S, Enjoji S, Hanasaki S, Hayase H, Yabe R, Tanaka Y, Nakagawa T, Liu HP, Chang SC, Usui T, Ohama T, Sato K. Sci Rep. 7: 4279. 2017 |
| Regulation of intestinal myofibroblasts by KRas-mutated colorectal cancer cells through heparin-binding epidermal growth factor-like growth factor | Kawasaki H, Saotome T, Usui T, Ohama T, Sato K. Oncol Rep. 37:3128-3136. 2017 |
| Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis | Usui T, Sakurai M, Kawasaki H, Ohama T, Yamawaki H, Sato K. Physiol Rep. 5:e13318.2017 |
| Effectiveness of the liver micronucleus assay using juvenile mice | Nagasue R, Murata I, Sasaki K, Sakai R, Miyajima H, Shimoda M. J Vet Med Sci. 79(7):1310-1317. 2017 |
| Expression of epithelial cell-derived cytokine genes in the duodenal and colonic mucosae of dogs with chronic enteropathy | Osada H, Ogawa M, Hasegawa A, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Kondo H, Ohmori K. J Vet Med Sci. 79(2):393-397. 2017 |
| CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? -inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration | Ogushi N, Sasaki K, Shimoda M. J Vet Med Sci. 79(2):320-327. 2017 |
| Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment | Usui T, Sakurai M, Enjoji S, Kawasaki H, Umata K, Ohama T, Fujiwara N, Yabe R, Tsuji S, Yamawaki H, Hazama S, Takenouchi H, Nakajima M, Tsunedomi R, Suzuki N, Nagano H, Sato K. Stem cells int. 7053872. 2016 |
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| Anti-tumor effects of perphenazine on canine lymphoma | Tsuji S, Yabe R, Usui T, Mizuno T, Ohama T, Sato K. J Vet Med Sci. 78:1293-1298. 2016 |
| Death-associated protein kinase 3 controls tumor progression of A549 cells through ERK MAPK/c-Myc signaling | Kake S and *Usui T, Ohama T, Sato K. Oncol rep. 37:1100-1106. 2016 |
| Regulation of Beclin 1 Protein Phosphorylation and Autophagy by Protein Phosphatase 2A (PP2A) and Death-associated Protein Kinase 3 (DAPK3) | Fujiwara N, Usui T, Ohama T, Sato K. J Biol Chem. 291:10858-10866. 2016 |
| Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs | Watanabe M, Osada H, Shimizu S, Goto S, Nagai M, Shirai J, Sasaki K, Shimoda M, Itoh H, Ohmori K. Am J Vet Res. 77(9):969-75. 2016 |
| Influence of glucocorticoids on a time-of-day-dependent variation in intradermal reactivity to histamine in dogs | Goto S, Shimizu S, Watanabe M, Osada H, Sasaki K, Shimoda M, Nagai M, Shirai J, Itoh H, Ohmori K. Vet J. 214:86-90. 2016 |
| Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle | Sawaguchi A, Sasaki K, Miyanaga K, Nakayama M, Nagasue M, Shimoda M. J Vet Med Sci. 78(9):1481-1485. 2016 |
| Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide | Elbadawy M, Ishihara Y, Aboubakr M, Sasaki K, Shimoda M. J Vet Med Sci. 78(6):1025-9. 2016 |
| Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation | Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K. PLoS One. 10:e0145226. 2015 |
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| The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma | Enjoji S, Yabe R, Fujiwara N, Tsuji S, Vitek MP, Mizuno T, Nakagawa T, Usui T, Ohama T, Sato K. J Vet Med Sci. 77:1451-1456. 2015 |
| Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells | Usui T, Nijima R, Sakatsume T, Otani K, Kameshima S, Okada M, Yamawaki H. Acta Physiologica (Oxf) 213:472-480. 2015 |
| Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review | Sasaki K, Shimoda M. J Adv Res. 6(3):383-92. 2015 |
| Oral pharmacokinetics of acetaminophen to evaluate gastric emptying profiles of Shiba goats | Elbadawy M, Sasaki K, Miyazaki Y, Aboubakr M, Khalil WF, Shimoda M. J Vet Med Sci. ;77(10):1331-4. 2015 |
| Effect of cyclosporin on distribution of methotrexate into the brain of rats | Ogushi N, Sasaki K, Shimoda M. J Vet Med Sci. ; 77(9):1171-3. 2015 |
| Oral pharmacokinetics of the acidic drugs, diclofenac and sulfamonomethoxine in male Shiba goats | Elbadawy M, Sakiyama T, Abohatab R, Sasaki K, Shimoda M. J Vet Med Sci. ; 77(1):21-6. 2015 |
| Characterization of SET/I2PP2A isoforms in dogs | Yabe R, Fujiwara N, Mizuno T, Usui T, Ohama T, Sato K. J Vet Med Sci. 76:1235-1240. 2014 |
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| Death-associated protein kinase3 mediates vascular structural remodeling via stimulating smooth muscle cell proliferation and migration | Usui T, Sakatsume T, Nijima R, Otani K, Kazama K, Morita T, Kameshima S, Okada M, Yamawaki H. Clin Sci (Lond). 127:539-548. 2014 |
| Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells | Usui T, Naruo A, Okada M, Hayabe Y, Yamawaki H. Acta Physiologica (Oxf). 211:385-394. 2014 |
| Histone deacetylase (HDAC) 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells | Usui T, Morita T, Okada M, Yamawaki H. Hypertension. 63:397-403. 2014 |
| Zipper interacting protein kinase (ZIPK): function and signaling | Usui T, Okada M, Yamawaki H. Apoptosis. 19:387-391. 2014 |
メディア等（Press release）
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8/21/2 研究成果展開事業 大学発新産業創出プログラム |
科学技術振興機構(JST)の研究成果展開事業 大学発新産業創出プログラム＜社会還元加速プログラム（ＳＣＯＲＥ）チーム推進型＞ に採択されました(三次元培養技術を用いたオーダーメイド獣医療システムの事業化検証)。 |
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6/12/20 日本の研究.com |
アミラさんの論文(Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture)が日本の研究.comで紹介されました。 |
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6/11/20 東京農工大学 |
アミラさんの論文(Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture)が大学のホームページで紹介されました。 |
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6/11/20 Eurek Alert! |
アミラさんの論文(Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture)がEurek Alert!英語版のホームページで紹介されました。 |
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4/3/20 TAT post |
学部5年生山中さんのラジオでのインタビューがYoutubeに公開されました(冒頭の3分と28分以降に出演)。 |
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2/24/20 日本経済新聞 |
日経新聞(朝刊)にNASHのオルガノイド論文の記事が掲載されました。 |
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2/20/20 医療新聞 DIGITAL |
医療新聞にNASHのオルガノイド論文の記事が掲載されました。 |
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2/14/20 医療NEWS |
医療ニュースでNASHオルガノイド論文が紹介されました。『非アルコール性脂肪肝炎の病態進行を再現するオルガノイド作出に成功－東京農工大ほか』 |
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1/25/20 日本獣医がん臨床研究グループ(JVCOG) |
猫乳がんオルガノイドプロジェクトが日本獣医がん臨床研究グループ(JVCOG)の実施中の臨床試験としてウェブに掲載されました。 |
| 8/1/20 日経産業新聞 |
研究成果が日経産業新聞(先端技術面)に掲載されました。『犬の抗がん剤、尿で効果確認』 |
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7/27/20 日本経済新聞 |
研究成果が日経新聞(ウェブ版)に掲載されました。『東京農工大、膀胱がん罹患犬の尿から膀胱がん組織の再現に成功』 |
特許等（Patent）
| 出願番号：特願2020-101200 イヌ中皮腫細胞株 |
発明者：臼井 達哉、打出 毅 出願人：国立大学法人東京農工大学 出願日：2020年6月10日 |
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| 出願番号：特願2020-051580 細胞培養体及びその製造方法 |
発明者：臼井 達哉、佐々木 一昭、モハメド エルバダウィー、篠原 佑太、山中 恵、林 希佳、後藤 悠太 出願人：国立大学法人東京農工大学 出願日：2020年3月23日 |
| 出願番号：特願2019-230780 非アルコール性脂肪肝炎マーカーおよびその利用 |
発明者：臼井 達哉、佐々木 一昭、モハメド エルバダウィー、篠原 佑太、山中 恵、林 希佳、後藤 悠太 出願人：国立大学法人東京農工大学 出願日：2019年12月20日 |